The Snail1/2/3 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to SNAI1, SNAI2, and SNAI3. This antibody recognizes Human, and Rabbit antigen. The Snail1/2/3 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated has been validated for the following applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Immunohistochemistry - frozen.
Description
The zinc finger transcription factor 'SNAIL' was first identified in Drosophila and, along with 'twist', a basic helix-loop-helix transcription factor, is indispensable for mesoderm formation. SNAIL is a repressor of mouse E-cadherin transcription, with expression of SNAIL inversely correlated with expression of E-cadherin. Abnormal expression of SNAIL could underlie the tumorigenic conversion of epithelia associated with loss of E-cadherin expression through screening mouse and human cell lines and by in situ hybridization of primary human tumors undergoing malignant progression